United States Senator Daniel K. Inouye, World War II veteran, Medal of Honor recipient and Hawaii's senior Senator,  has died.  Inouye passed away from respiratory complications at 5:01 p.m. EST Monday at the Walter Reed National Military Medical Center.  His wife Irene and his son Ken were at his side.  Last rites were performed by Senate Chaplain Dr. Barry Black.

At the time of his death, Inouye was serving as the Senate President pro tempore, third in the line of succession for the presidency behind Vice President Joe Biden and House Speaker John Boehner.

FOX News Radio's Jared Halpern reports:

Sen. Inouye died of respiratory complications; he's been hospitalized for some time at Walter Reed Hospital in nearby Bethesda, Maryland.  

Inouye has served in Congress as long as Hawaii has been a state - first serving in Congress in 1959.  He served two terms as the first House member from the 50th state, then serving as Senator for nine terms.  His storied tenure began as a freshman House member, initially with no staff when he first arrived on Capitol Hill.  Just last year, he recalled an early conversation with then-Speaker Sam Rayburn, who called his office.  He said, at that time, "I was there by myself and answered the telephone, and the voice said, 'I'm looking for a Congressman from Hawaii.  I can't pronounce his name, but his first name is Dan.'"

The story of Dan Inouye is the story of modern Hawaii.  During his eight decades of public service, Dan Inouye helped build and shape Hawaii.  Sen. Inouye began his career in public service at the age of 17 when he enlisted in the U.S. Army shortly after Imperial Japan attacked Pearl Harbor on December 7, 1941.  He served with 'E' company of the 442 Regimental Combat Team, a group consisting entirely of Americans of Japanese ancestry.  Senator Inouye lost his arm charging a series of machine gun nests on a hill in San Terenzo, Italy on April 21, 1945.  His actions during that battle earned him the Medal of Honor.

Following the war, he returned to Hawaii and married Margaret "Maggie" Awamura, and graduated from the University of Hawaii and the George Washington University School of Law.  After receiving his law degree, Dan Inouye, returned to Hawaii and worked as a Deputy Prosecuting Attorney for the City and County of Honolulu.  He recognized the social and racial inequities of post-war Hawaii, and in 1954 was part of a Democratic revolution that took control of the Territorial Legislature.

Following statehood in 1959, Dan Inouye was privileged to serve as Hawaii's first Congressman.  He ran for the Senate in 1962 where he served for nearly nine consecutive terms.  Dan Inouye spent his career building an enduring federal presence in Hawaii to ensure that the state would receive its fair share of federal resources.

He worked to expand the military's presence on all major islands, stabilizing Pearl Harbor, building up the Pacific Missile Range and constructing a headquarters for the United States Pacific Command.  He has worked to build critical roads, expanded bus services statewide and secured the federal funds for the Honolulu Rail Transit project.  He championed the indigenous rights of Native Hawaiians and the return of Kahoolawe.

He fought for the rights and benefits for veterans.  Sen. Inouye has left an indelible mark at the University of Hawaii, including support for major facilities and research assets.  He has long supported local agriculture and alternative energy initiatives.  Dan Inouye was always among the first to speak out against injustice whether interned Japanese Americans, Filipino World War II veterans, Native Americans and Native Hawaiians.

A prominent player on the national stage, Sen. Inouye served as Chairman of the Senate Committee on Appropriations, the Senate Commerce Committee and was the first Chairman of the Senate Select Committee on Intelligence.  After developing a reputation as a bipartisan workhorse,  who always would put country above party, he was asked by the Senate leadership to chair the special committee investigating the Iran Contra Affair.  This was after a successful tenure as a member of the Watergate Committee.

When asked in recent days how he wanted to be remembered, Dan said, very simply, "I represented the people of Hawaii and this nation honestly and to the best of my ability. I think I did OK."

He is survived by his wife, Irene Hirano Inouye, his son Daniel Ken Inouye Jr., Ken's wife Jessica, and granddaughter Maggie and step-daughter Jennifer Hirano.  He was preceded in death by his first wife, Maggie Awamura.

His last words were, "Aloha."

Read a statement by the President on the Passing of Senator Daniel Inouye:

Tonight, our country has lost a true American hero with the passing of Senator Daniel Inouye. The second-longest serving Senator in the history of the chamber, Danny represented the people of Hawaii in Congress from the moment they joined the Union. In Washington, he worked to strengthen our military, forge bipartisan consensus, and hold those of us in government accountable to the people we were elected to serve. But it was his incredible bravery during World War II - including one heroic effort that cost him his arm but earned him the Medal of Honor - that made Danny not just a colleague and a mentor, but someone revered by all of us lucky enough to know him. Our thoughts and prayers are with the Inouye family.

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